The Boston Red Sox (30-35) and New York Yankees (39-23) play the second game of their 3-game series Saturday. First pitch from Yankee Stadium is set for 7:35 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Red Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Mayer’s home run is the lone positive for Boston so far in this game. The Sox trail 8-1 in the sixth inning. The Yankees pounded starter Walker Buehler for seven runs (five earned), seven hits, two homers and two walks in the first two innings.

After being hammered 7-0 to start off their rivalry game vs. the Yankees, the Red Sox's pitching woes hit a brutal low for the 2025 MLB season