After Demi Moore lost the best actress Oscar to a younger star, Mikey Madison, fans of "The Substance" couldn't help but point out the irony.

Hollywood veteran Demi Moore of “The Substance” had been the Oscar front-runner, having won over Madison at the Golden Globes and SAG Awards. However, Madison beat out Moore for the BAFTA two days before Oscar voting ended, as well as at last weekend’s Independent Spirit Awards.

Director Sean Baker’s Anora — which won five Oscars, including best picture — centers on Ani (Madison), a young sex worker who impulsively marries the son of a powerful Russian businessman. During her acceptance speech, Madison said she appreciated the chance to honor the sex worker community.