The two main mouse models used to study myelin damage and repair in MS each replicate certain distinct biological features of ...

Nerve fibers in the brain and spinal cord are wrapped in an insulating sheath known as myelin. For a long time, this barrier, which is essentially the brain's white matter, was believed to serve the ...

Oligodendrocytes are joining astrocytes and microglia as members of a glial syndicate involved in the pathology of amyotrophic lateral sclerosis, according to a paper in the March 31 Nature ...

Osteocalcin (OCN) is a multifunctional bone-derived hormone that modulates numerous physiological activities. OCN can cross the blood brain barrier (BBB) and thus play critical roles in neuronal and ...

Johns Hopkins scientists say they have used 3D imaging, special microscopes and artificial intelligence (AI) programs to construct new maps of mouse brains showing a precise location of more than 10 ...

Stroke is a leading cause of death and disability, affecting 1 in 4 people during their lifetime. Stroke happens when blood vessels in the brain get clogged or damaged, impairing blood flow and oxygen ...

The results of preclinical studies headed by investigators at the UK Dementia Research Institute at University College London, and colleagues, suggest that non-neuronal brain cells called ...

New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple ...

Summary: The myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry. We have ...

JoAnn Buchanan, Ph.D., was deep into the data. One click at a time, she scanned through the branching, twisting 3D shapes of mouse brain cells on her computer screen. And then Buchanan, a scientist at ...