Background: Selective serotonin reuptake inhibitors are increasingly used in the long-term treatment of depression. Much of the supporting evidence about the effects of these drugs comes from ...

A phase 2 trial suggests that the novel SNRI ammoxetine may effectively treat major depressive disorder while avoiding some ...

Monoamine oxidase inhibitors were linked to the highest risk for cardiovascular Standardized MedDRA Queries. Dopamine reuptake inhibition and binding inhibition are linked to antidepressant-related ...

Duloxetine is a dual inhibitor of norepinephrine (NE) and serotonin (5-HT) uptake. Initial trials conducted in depressed patients using regimens of 20 mg/day or less did not convincingly demonstrate ...

Objective To compare the efficacy and tolerability of tricyclic antidepressants with selective serotonin reuptake inhibitors in depression in primary care. Design Systematic review and meta-analysis ...

A popular antidepressant, often known by the brand name Cymbalta, was recalled last week due to the presence of a potentially cancer-causing chemical. More than 233,000 bottles of duloxetine capsules ...

About 5% of adults worldwide live with depression, a mental health condition characterized by feelings of sadness, hopelessness, and an inability to experience joy. One common treatment for depression ...

Ian Goodyer, Bernadka Dubicka, Paul Wilkinson, Raphael Kelvin, Chris Roberts, Sarah Byford, Siobhan Breen, Claire Ford, Barbara Barrett, Alison Leech, Justine ...

Introduction: Fibromyalgia (FM) is often comorbid with anxiety and depression. Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used in the treatment of FM, depression, and anxiety, but ...

Some antidepressants, such as fluoxetine (Prozac), work by preventing neurons from vacuuming up the neurotransmitter serotonin from the gaps between brain cells—a process called reuptake. By doing so, ...