GEN - Genetic Engineering and Biotechnology News

Enzymes Involved in Cholesterol Transport May Point to New Cancer Therapies

Researchers suggest targeting mTOR activity in aggressive cancers by blocking cholesterol sensing may represent a promising ...
The Scientist

The Loss of Cholesterol Transport Enzymes Impedes Tumor Growth

Kinases that shuttle cholesterol within tumor cells help fuel growth. Blocking these enzymes may starve cancer cells, ...
ascopubs.org

The bi-steric mTORC1-selective inhibitor RMC-5552 in tumors with activation of mTOR signaling: Preclinical activity in combination with RAS(ON) inhibitors in RAS-addicted ...

A phase 1, first-in-human, dose-escalation and biomarker trial of liposomal gemcitabine (FF-10832) in patients with advanced solid tumors. This is an ASCO Meeting Abstract from the 2022 ASCO Annual ...
AlphaGalileo

Paligenosis: dual potential of mature cell plasticity in regeneration and tumorigenesis

Paligenosis defines a tightly controlled program through which terminally differentiated cells re‑enter the cell cycle and ...
News Medical

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

In a recent study published in Nature Metabolism, researchers conducted clinical studies on murine animals and humans to evaluate the impact of high protein intake on the amino acid-mammalian target ...
ascopubs.org

Characterizing patterns of mTORC1 activation across sarcoma subtypes using single-sample gene set enrichment analysis (ssGSEA) and a national biomarker database.

Predictive gene signature for trabectedin efficacy in advanced soft‐tissue sarcoma: A Spanish group for research in sarcoma (GEIS) study. New soft tissue sarcoma (STS) transcriptomic clusters to ...