Opioid cross-reactivity is the uncommon occurrence of having an allergic reaction to more than one opioid. Allergies to opioids present a unique challenge in pain management due to the limited ...

April 2, 2009 — Long-term use of opioids to manage chronic pain increases patients' sensitivity to certain types of pain, and similar hyperalgesia develops with methadone-maintained drug abusers, ...

The Annals of Pharmacotherapy. 2006;40(7):1327-1335. The classification of opioid analgesics may be based on 3 different schemes: (1) analog class (phenanthrene, phenylpiperidine, diphenylheptane), (2 ...

In a recent study published in the journal Scientific Reports, researchers at Yale University School of Medicine evaluated the potential effects of a ketogenic diet (KD) on oxycodone responses in a ...

The rewarding properties of opioids are essential driving force for compulsive drug-seeking and drug-taking behaviors in the development of opioid-mediated drug addiction. Prior drug use enhances ...