WASHINGTON–Iran’s Supreme Leader Ali Khamenei is “not off limits” from targeting as Israel proceeds with its intensive air campaign in Iran, an Israeli official said Saturday. The official said Israel wasn’t ruling out any potential targets to destroy the nuclear program,

Israel's killing of IRGC senior command left the clerical regime exposed to rebellion and transnational rivals, foreign policy expert Carlo J.V. Caro argues

The countries have been trading blows a day after Israel’s blistering attack on Iranian nuclear and military sites.

Emergency services say 10 have been killed in Israel, while Iranian state media has given little information about casualties in Iran.

"The full strength and might of the U.S. Armed Forces will come down on you at levels never seen before," Trump warned.

The conflict between Israel and Iran - once played out in a series of proxy wars - has escalated. On Friday morning, explosions hit Tehran as Israel carried out a major attack on its nuclear capabilities. Iran threatened "severe punishment" and quickly retaliated with a wave of missiles.

According to a report from the Jerusalem Post, Muhammad Abd al Karim al Ghamari, the chief of staff for the Houthis, was the main target of the strike.

"There has already been great death and destruction, but there is still time to make this slaughter... come to an end," Trump wrote on social media.