The push to do a deal on the country’s nuclear program could be revived, even after the Israeli strikes scuppered the latest round of talks.

Israeli PM Netanyahu claims airstrikes have severely damaged Iran's nuclear program and weakened its regime. As explosions rock Tehran, he warns collapse is possible; Trump urges Iran to resume talks.

As the attacks escalate, with fatalities and injuries reported on both sides, Israel issued the stark warning to Iran.

Israel’s attack on Iran was long in the making – the result of years of meticulous planning by Israel and days of high-stakes talks between Tel Aviv and Washington, officials told CNN.

European Commission president Ursula von der Leyen said she told Israeli Prime Minister Benjamin Netanyahu on Sunday that diplomacy was ultimately best on Iran, but stopped short of calling for an immediate ceasefire.

Israeli Prime Minister Benjamin Netanyahu raised the possibility of strikes in a phone conversation with President Trump, according to two U.S. officials. Trump responded that he would like to see diplomacy run its course before turning to military options.

Russian President Vladimir Putin, in separate telephone conversations on Friday, told Iran's president that Moscow condemned Israel's actions against Tehran and told Israel's prime minister that questions around Iran's nuclear programme could only be solved through diplomacy.

As Israel escalates strikes on Iran’s nuclear facilities, fears grow that the conflict could spill over into a global war. With the US cautious, Russia posturing, and regional powers on edge, the Israel-Iran clash has sparked heated debate over whether World War III has begun.

In an ABC News exclusive, Israeli PM Benjamin Netanyahu speaks with Jon Karl about the conflict with Iran -- and says he's not ruling out taking out Iran's supreme leader, Ali Khamenei.