Gut

Luminal–basal stratification of the native human pancreatic duct is differentially represented in pancreatic cancers

Background A resemblance of pancreatic tumours to their native tissue architecture remains largely unexplored, while it may ...
gut.bmj

Mechanisms of intestinal adaptation in short bowel syndrome: what is the evidence?

Short bowel syndrome (SBS) is defined by a remaining small bowel length of less than 200 cm after surgical resection and is a condition with significant clinical implications and a high risk of ...
Gut

From preclinical phase of Crohn’s disease to postoperative recurrence: shared mechanisms and potential interventions

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with high risk of surgery. Despite advances in medical treatment, of those patients who undergo ileocolonic ...
gut.bmj

Physical activity reshapes intrapancreatic immune and inflammatory programmes to restrain chronic pancreatitis

Background Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder with persistent immune activation and limited therapeutic options. While physical activity (PA) benefits many chronic ...
Gut

Autoimmune gastritis: a hidden gateway to cardia and oesophageal cancers beyond non-cardia gastric adenocarcinoma

Autoimmune gastritis (AIG) has been traditionally recognised as a precursor to type I gastric neuroendocrine tumours and ...
gut.bmj

OLGIM staging and proton pump inhibitor use predict the risk of gastric cancer

Correspondence to Dr Yoku Hayakawa, Department of Gastroenterology, Graduate school of medicine, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; yhayakawa-tky{at}umin.ac.jp; Dr Ryota ...
gut.bmj

Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)

Background: The colonic epithelium maintains a life long reciprocally beneficial interaction with the colonic microbiota. Disruption is associated with mucosal injury. Aims: We hypothesised that ...
gut.bmj

The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

4 Department of Hepatogastroenterology, Hopital Claude Huriez, CHRU Lille, France Correspondence to: Professor J-F Colombel Department of Hepato-Gastroenterology, Hopital Claude Huriez, CHRU de Lille, ...
gut.bmj

Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis

Objective The benefits of pancreatic enzyme replacement therapy (PERT) in chronic pancreatitis (CP) are inadequately defined. We have undertaken a systematic review and meta-analysis of randomised ...
gut.bmj

Online First

Environmental impacts of single-use versus reusable duodenoscopes for endoscopic retrograde cholangiopancreatography in Germany: an ISO-compliant cradle-to-grave life cycle assessment ...
gut.bmj

PTEN deficiency impairs MHC-I-mediated tumour immunity via NRF2-dependent autophagy in microsatellite stable colorectal cancer

Background Immune checkpoint blockade (ICB) has limited efficacy in microsatellite stable (MSS) colorectal cancer (CRC) due to an immunosuppressive tumour microenvironment. Although loss of ...
gut.bmj

Blocking MOXD1-derived ACOX1 peroxisome trafficking suppresses metabolic dysfunction-associated steatohepatitis

1 State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute; School of Pharmacy; First Affiliated Hospital, ...