reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but ...
The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...
Oregon Health and Science University 3181 SW Sam Jackson Park Road Mail Code CR 131 Portland, OR97239 United States Visit Website Contact: Jeffrey Kaye, M.D. Phone: 503-494-6976 Fax: 503-494-7499 ...
Contact Information Ryan Castro, Ph.D. Charlestown, United States Professional Information Postdoctoral Research FellowMassachusetts General Hospital ...
Scientists led by Wiep Scheper of Amsterdam University Medical Center are flipping the script on granulovacuolar degeneration bodies. Historically, GVBs have been considered a sign of impending ...
Studies have confirmed the existence of neurogenesis in the adult human brain, but whether newborn neurons bolster cognitive abilities remains controversial. In the February 25 Nature, scientists led ...
A bad bout with pneumonia can do more than mess with the lungs—it can also hasten cognitive decline and even the onset of Alzheimer’s disease. While the mechanisms at work in this double whammy remain ...
The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...
The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...
Lomecel-B is a preparation of multipotent stem and progenitor cells isolated from donated bone marrow of young healthy adults, and expanded in culture. The cells are administered by intravenous ...
Under physiological conditions TDP-43 is primarily nuclear, but in some people with ALS and FTD the protein relocates to the cytoplasm where it accumulates into hallmark inclusions. To investigate the ...